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KMID : 0986520120120030166
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Korean Journal of Endoscrine Surgery
2012 Volume.12 No. 3 p.166 ~ p.171
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Association between Preoperative Serum TSH Level and Papillary Thyroid Cancers
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Song Geum-Jong
Han Sun-Wook
Lee Jin-Hyung
Woo Hee-Doo
Kim Sung-Yong
Kim Jae-Woo
Park Nae-Kyeong
Baek Moo-Jun
Kim Chang-Ho
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Abstract
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Purpose: Recent research has shown that there is a relationship between the level of preoperative serum TSH and a papillary thyroid carcinoma. Therefore, this study examined the correlation between the serum TSH and papillary thyroid carcinoma.
Methods: The preoperative serum TSH level of papillary thyroid carcinoma and nodular hyperplasia of 418 patients from 2009 Jan. to 2011 Dec. was examined. The patients were divided into 3 groups, nodular hyperplasia, less than 1 cm micropapillary ca:rcinoma and more than 1 cm papillary carcinoma, and their TSH levels were compared.
Results: Nodular hyperplasia and total papillary carcinoma was found in 98 (23.0%) and 322 (77.0%) patients, respectively. After dividing the patients according to the size of the mass, there were 224 (53.6%) patients with a mass less than 1 cm in size and 98 (23.4%) patients with a mass more than 1 cm in size. The preoperative serum TSH level of the 3 groups showed a significant difference, which was in the nodular hyperplasia group, in the micropapillary carcinoma group and in the papillary carcinoma group (P<0.001). On the other hand, there were no significant correlations between the preoperative serum TSH level and gender, age, metastasis to lymph node, number of masses and extrathyroidal extensions.
Conclusion: The larger size of the papillary thyroid carcinoma, the higher the preoperative high serum TSH level. Therefore, the stimulation of TSH can affect the progression of papillary thyroid carcinoma but more study will be needed.
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KEYWORD
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Thyroid cancers, Papillary thyroid carcinoma, TSH
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